Gut Microbiota Profiles of The Osteoporotic Hip Fracture Patients with and without CKD and Their Relationship with Metabolic Bone Panels

• Conditions: Fragility hip fractures; Fragility hip fractures, gut microbiota

• Registration Number: TCTR20230905003
• Lead Sponsor: Faculty of medicine research fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-09-05
• Study Completion: 2023-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. The patients that older than 50 years
2. The patients that have been diagnosed with Osteoporotic hip fracture, caused by falling on the ground or low energy trauma.

Exclusion Criteria

1. The patients that diagnosed with pathologic hip fractures
2. The patients that diagnosed with multiple fracture
3. The patients that received antibiotic drugs in 90 days before the admission

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gut microbiota's genetic extraction from patient's feces Before patient is get the surgery Feces extraction by using QIAGEN. PCR amplification and sequencing for amplify microbial 16S rRNA gene. Identify by using QIIME2 package. Classify for analysis by using scikit-learn naive Bayes.

Secondary Outcome Measures

Name	Time	Method
Correlation between gut microbiota profiles and metabolic bone parameters in the osteoporotic hip fracture patients with CKD and without CKD. Before patient is get the surgery Feces extraction by using QIAGEN. PCR amplification and sequencing for amplify microbial 16S rRNA gene. Identify by using QIIME2 package. Classify for analysis by using scikit-learn naive Bayes.