Effects of an intravenous acetaminophen/ibuprofen fixed-dose combination on postoperative sore throat in patients undergoing gynecological surgery: a prospective, randomized, placebo-controlled, double-blind study

Konyang University Hospital0 个研究点目标入组 108 人开始时间: 待定最近更新: 2022年9月20日

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•1. Female patients aged 19 to 64 who require endotracheal intubation during gynecological surgery
•2. According to the American Society of Anesthesiologist's physical status classification, 1 to 3 patients.

•- Patients with sore throat, cough, and hoarseness before surgery
•- Patients with symptoms of upper respiratory tract infection before surgery
•- Patients who are expected difficult intubation
•- Psychiatric patients
•- Patients with cognitive impairment
•- Contraindicated use of acetaminophen or ibuprofen (e.g., history of hypersensitivity reactions, gastrointestinal ulcers, severe renal impairment)
•- When the surgical method is changed from laparoscopic to laparotomy during surgery
•- Patients with active alcoholism
•- Patients with severe blood abnormalities, severe liver disorders, severe kidney disorders, severe heart failure, and severe hypertension
•- Patients with asthma or a history
•- Patients with pain before and after coronary artery bypass surgery
•- If you are taking concomitant medications (eg, barbiturates, tricyclic antidepressants, high-dose methotrexate)
•- In other cases where the researcher is considered inappropriate

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