The Effect of Anaesthetic Preconditioning on Lung Injury during One Lung Ventilation undergoing Transthoracic Esophagectomy

Phase 4

Completed

• Conditions: esophageal cancer; Anaesthesiology - Anaesthetics; Cancer - Oesophageal (gullet)

• Registration Number: ACTRN12610000410055
• Lead Sponsor: Jie Ae Kim

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

American Society of Anaesthesiologists physical status I-III undergoing transthoracic esophagectomy

Exclusion Criteria

high body temperature (over 37degrees celsius), increased levels of C-reactive protein (CRP) and white blood cell (WBC), administration nonsteroidal anti-inflammatory agent (NSAIDs) or corticosteroid within 3months, vital capacity (VC) or peak expiratoty volume at 1 minute (FEV1) less than 50% of expected.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
interleukin-6 plasma levels assessed by blood analysis[just before the start of one lung ventilation and at end of operation]

Secondary Outcome Measures

Name	Time	Method
blood malondialdehyde[just before the start of one lung ventilation and at end of operation];chest radiography[immediately prior to the operation and postoperative 1 day];complications: anastomosis leakagewill be assessed clinically, arrhythmia by electrocardiogram (ECG), lung complications by physical signs and laboratory tests, and wound dehiscence will be assessed clinically[within 7 days, postoperatively, it will be assessed as problems arise]