Study to Determine the Immune Response From Broncho-alveolar Cells Against Pigeon Specific Antigens
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Extrinsic Allergic Alveolitis
- Sponsor
- Bossink, A.W.J.
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- ELISPOT response in cells obtained from broncho-alveolar lavage
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens. The hypothesis is: cells in BAL lavage fluid from patients with EAA will be responsive to specific antigens and this response can be measured using ELISPOT.
Detailed Description
Subjects suffering from extrinsic allergic alveolitis caused by pigeons will undergo a broncho alveolar lavage. Cells obtained from this BAL will be used for ELISPOT technique with pigeon specific antigens
Investigators
A.W.J.Bossink
Dr
Bossink, A.W.J.
Eligibility Criteria
Inclusion Criteria
- •suspicion of pigeon induced extrinsic alveolitis
Exclusion Criteria
- •use of oral steroids
- •unable to give informed consent
- •age below 18
Outcomes
Primary Outcomes
ELISPOT response in cells obtained from broncho-alveolar lavage
Time Frame: 2 days
All elispots will be performed the same day, the end point will be available the next day
Secondary Outcomes
- Elispot response in cells from blood(2 days)