Immunological Characterization of Bronchoalveolar Cells in Normals
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Disease
- Sponsor
- Ohio State University
- Enrollment
- 1232
- Locations
- 1
- Primary Endpoint
- comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
To obtain the monocytes (white blood cells) from normal volunteers for the purpose of studying how proteins, fats, carbohydrates, as well as RNA and DNA for gene expression, relate to immunity. This information will be compared to other studies in patients with lung diseases such as Emphysema, Sarcoidosis, and Interstitial Pulmonary Fibrosis.
Detailed Description
To determine the functional capabilities of cells obtained from bronchoalveolar lavage fluid and peripheral blood monocytes from normal individuals. The ongoing objective varies from investigation to investigation but in general the investigational goals are to better understand the immune function of monocytes purified from normal volunteers. In some instances the emphasis will be upon comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages. This comparison is not the only goal of the study, however. In many cases the immune function of the monocyte will be sufficient in and of itself as an investigational goal. In other cases the same is true of alveolar macrophage function.
Investigators
Mark D. Wewers, MD
Associate Director of Pulmonary Research
Ohio State University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •unable to consent
Outcomes
Primary Outcomes
comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages
Time Frame: end of study
Secondary Outcomes
- Analysis of lung proteins present in BAL fluid(end of study)