The effects of curcuminoid on esophageal and gastric function in patients with gastroesophageal reflux disease

Phase 2

Active, not recruiting

• Conditions: Gastroesophageal reflux disease (GERD) and acid reflux in the esophagus is excessive.; curcuminoid, gastroesophageal reflux, gastric emptying, gastric accommodation.

• Registration Number: TCTR20180530008
• Lead Sponsor: Government Pharmaceutical Organization (GPO)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-05-30
• Study Completion: 2020-02-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Patients who have been diagnosed with acid reflux for at least 3 months
2. Age 18 - 70 years
3. Have had gastrointestinal endoscopy in the last 6 months prior to study.
4. The results of acid measurement in the esophagus found that acid reflux in the esophagus is excessive.

Exclusion Criteria

1. Surgery in the abdomen except appendicitis, Maternity leave

2. Cancer of the gastrointestinal tract and liver

3. chronic inflammatory bowel disease inflammatory bowel disease

4. Cirrhosis, Chronic kidney disease

5. Depression

6. Upper gastrointestinal endoscopy results in 6 months before admission. The following abnormalities were observed: esophagus, gastric ulcer and duodenal ulcer.

7. Helicobacter pylori infection

8. Patients who take the drug with gastrointestinal effects and can not off the drug during research.

9. There are neurological diseases that can not be evaluated for pain. Uncontrolled psychiatric disorders and may want to adjust the drugs during study.

10. Have allergic curcumin.

11. Eat foods that component curcumin, regularly at least 3 days a week during the 1 month prior to study

12. Patients who can not sign the consent form for study participation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference of values measured by 24 hour impedance pH monitoring After 4 weeks of intervention 24 hour impedance pH monitoring

Secondary Outcome Measures

Name	Time	Method
Gastrointestinal symptoms after drug administration and side effects. After 4 weeks of intervention 24 hour impedance pH monitoring ,The relationship between acid reflux symptoms. After 4 weeks of intervention 24 hour impedance pH monitoring