Comparative study of effectiveness of intravenous high dose of vitamin C and vitamin B1 in patients with severe infection.
Phase 2
- Conditions
- Health Condition 1: B978- Other viral agents as the cause ofdiseases classified elsewhereHealth Condition 2: B348- Other viral infections of unspecified siteHealth Condition 3: O85- Puerperal sepsisHealth Condition 4: A419- Sepsis, unspecified organismHealth Condition 5: B999- Unspecified infectious disease
- Registration Number
- CTRI/2024/03/063852
- Lead Sponsor
- ttar Pradesh University of medical sciences saifai etawah
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients with body mass index between 18 to 30
2.Patient who will not be on mechanical ventilator but fulfilling the criteria of sepsis at the time of inclusion for study
3.Patient who will be on standard treatment with similar antibiotics
4.Patient with SOFA score more than 2 but less than 8 will be included in the study.
Exclusion Criteria
1.Pregnant or breastfeeding females
2.Moribund and not expected to survive 96 hours
3.Cancer as the cause of sepsis
4.Patients with chronic kidney disease, chronic alcoholics and immuno-compromised
patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the SOFA (Sequential Organ Failure Assessment) score.Timepoint: 6 days
- Secondary Outcome Measures
Name Time Method 1. Incidence of ventilator associated pneumonia (VAP) if patient requires <br/ ><br>mechanical ventilation after inclusion in study. <br/ ><br>2. Duration of vasopressor therapy <br/ ><br>3. CRP levels <br/ ><br>4. Length of hospital stay <br/ ><br>5. Mortality <br/ ><br>6. Serious adverse events like ARDS, pulmonary embolism.Timepoint: 6 days