NCT02265003CompletedNot Applicable
Red Blood Cells as a Reflection of Endothelial Function in Old Age
Heinrich-Heine University, Duesseldorf1 site in 1 country140 target enrollmentStarted: July 2012Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 140
- Locations
- 1
- Primary Endpoint
- Determination of endothelial function
Study Overview
Brief Summary
The aim of this study is to find out, how far red blood cells reflect age-depended changes in endothelial function.
Detailed Description
It will be investigated with determination of endothelial function (measured as flow-mediated vasodilation) and of circulated nitric oxid-pool in red blood cells and in blood plasma, how far red blood cells reflect age-depended changes in endothelial function.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy subjects
- •informed consent
Exclusion Criteria
- •hypertension (blood pressure ≥140/90 mmHg),
- •hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
- •diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
- •acute inflammation (CRP >0.5 mg/dl)
- •malignant diseases
- •heart failure (NYHA III-IV)
- •arrhythmia of high degree
- •acute or terminated kidney disease
- •cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
- •pregnancy
- •Inclusion Criteria:
- •angiographical signs of apparent atherosclerosis (cardiac artery disease or peripheral vascular disease or degenerative valvular heart disease)
- •informed consent
- •Exclusion Criteria:
- •Hypertension (blood pressure ≥140/90 mmHg),
- •Hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
- •Diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
- •acute inflammation (CRP >0.5 mg/dl)
- •malignant diseases
- •heart failure (NYHA III-IV)
- •arrhythmia of high degree
- •acute or terminated kidney disease
- •cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
- •pregnancy
Outcomes
Primary Outcomes
Determination of endothelial function
Time Frame: baseline
measured as flow-mediated vasodilation
Secondary Outcomes
- Determination of nitric oxide(NO)-pool in red blood cells and blood plasma(baseline)
- Determination of erythrocytes parameter(baseline)
- Cardiovascular Parameter(baseline)
Investigators
Klinik für Kardiologie, Pneumologie und Angiologie
Principle Investigator Prof. Dr. Malte Kelm
Heinrich-Heine University, Duesseldorf
Study Sites (1)
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