Electrophysiological Study of the Effects of Limb Cooling on Essential Tremor
Not Applicable
Completed
- Conditions
- Tremor
- Registration Number
- NCT01093027
- Lead Sponsor
- Mayo Clinic
- Brief Summary
To determine the effects of upper limb forearm cooling on Essential Tremor upper limb tremor using a more practical method of limb cooling through a forearm cold pack.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Patients with clinical diagnosis of E.T. for at least a year by a movement disorder neurologist
- A +2 or worse action or kinetic tremor of one or both upper limbs involving at least the forearm and/or hand
- Ages 18 to 95 years old
Exclusion Criteria
- (+) sensory loss in the upper extremities
- dermatologic lesions in upper extremities (e.g. skin cancer, eczema, fresh or healing wounds, abrasions, acne, pustules, abscesses, or skin rash)
- known history of sensitivity to cold (i.e., cold urticaria)
- known peripheral vascular disease
- Raynaud's phenomenon
- scleroderma
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Tremor Amplitude After 10 minutes of limb cooling treatment. Average tremor amplitude during the Outstretched, Abducted, Nose, and Mug conditions of the Tremor Rating Scale test.
- Secondary Outcome Measures
Name Time Method Tremor Rating Scale After 10 minutes of limb cooling treatment. Arm tremor severity was rated on a scale from 0=None to 4=Severe during each of four conditions: arm outstretched, hand close to mouth and arm abducted, performing a finger to nose maneuver, and holding a mug. The Tremor Rating Scale score was the mean of the scores for the four conditions, and ranged from a score of 0=None to 4=Severe.
Trial Locations
- Locations (1)
Mayo Clinic Arizona
🇺🇸Scottsdale, Arizona, United States
Mayo Clinic Arizona🇺🇸Scottsdale, Arizona, United States