Epigenetic effects of exposure to pre-, peri- and postnatal stress assessed in early infancy (subproject 1 of Prä-, peri- und pOstnatal Stress in human and non-human offspring: Epigenetic Impact on DepressiON (POSEIDON)) / DIAbetes Mellitus - Obstetric and Neonatal Distress: Epigenetic Effects (DiaMOND E2)

Recruiting

• Conditions: F32; E11; Depressive episode; Type 2 diabetes mellitus

• Registration Number: DRKS00003600
• Lead Sponsor: Zentralinstitut für Seelische Gesundheit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 400

Inclusion Criteria

mother = main caregiver, German-speaking, no severe physical disease, no psychiatric disorder requiring inpatient treatment, birth weight > 1500 gr, gestational age > 32 weeks, AGPAR > 7

Exclusion Criteria

twin birth, major birth trauma of child or other major handicap

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
As outcome variables, we will investigate genome-wide methylation patterns (cord blood at birth) in extreme groups and their changes during early infancy (buccal mucosa swab at birth and 6 months).

Secondary Outcome Measures

Name	Time	Method
Methylation of promoters of candidate genes for depression and diabetes and their change during course of observation (birth, 6 months postpartal).