Evaluation of the psychobiological, epigenetic and psychometrically assessable effects of a mindfulness based stress reduction program
Not Applicable
- Conditions
- chronic stress, resilience
- Registration Number
- DRKS00013950
- Lead Sponsor
- niversitätsklinikum Heidelberg Institut für Medizinische Psychologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
1. Medical students in their preclinical stage enrolled at the Heidelberg medical faculty
2. Age = 18 years
3. Initial contact in order to describe and elucidate participants regarding the study procedures
4. Internet access for participating in the ecological momentary assessment procedures
5. Provision of written consent
Exclusion Criteria
1. Chronic serious physical diseases (especially endocrionological, cardiovascular, neurological, nephrological and hepatic diseases)
2. Chronic serious psychiatric diseases (especially schizophrenic spectrum disorders, severe depression and bipolar disorders)
3. Heavy smoking (= 20 cigarettes daily)
4. Current substance abuse or addictive disorders
5. Permanent intake of psychotropic drugs
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Promoter methylation and mRNA expression as well as the polymorphisms 5-HTTLPR and rs25531 of the SLC6A4 gene are measured from blood. The circadian rhythms of cortisol and alpha-amylase are measured from saliva. Psychometrically assessed stress, mindfulness and coping strategies in everyday life are measured via ecological momentary assessment. All primary endpoints, except polymorphisms, are measured at pre- and post-intervention.
- Secondary Outcome Measures
Name Time Method Distress tolerance, psychiatric symptoms, interpersonal behavior and empathy, resilience, personality traits, self-compassion, experience of social systems, mindfulness, social support, coping strategies, early life stress, chronic stress, burnout, chronotype, quality of sleep and recent life stress. All secondary endpoints are measured via questionnaires at pre- and post-intervention.