The role of tissue factor pathway inhibitor in the development and progression of ischemic cerebral lesions due to cerebral micro-angiopathy
Completed
- Conditions
- Lacunar stroke. Stroke.1000796310014523
- Registration Number
- NL-OMON31866
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Adult patients with symptomatic lacunar stroke in the past 5 years.
and healthy controls (>18 years old)
Exclusion Criteria
History of intracranial or major extracranial bleeding
Use of oral anticoagulants
Hemorrhagic diathesis
Allergy for heparin
For healthy controls:
History of cardiovascular events (stroke, myocardial infarction or periphery artery disease)
Known cardiovascular risk factors (hypertension, diabetes mellitus).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Plasma concentration of TFPI before and after administration of heparin in<br /><br>controls and lacunar stroke patients.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>