The Impact of Non-pulsatile Blood Flow on CO2-Reactivity

Not Applicable

Completed

• Conditions: Cerebrovascular Circulation
• Interventions: Procedure: alteration of PaCO2 level

• Registration Number: NCT03732651
• Lead Sponsor: Medical University of Vienna

Brief Summary

The investigators hypothezised that CO2-reactivity of cerebral vessels is affected by systemic non-pulsatile blood flow. Patients undergoing elective cardiac surgery with CPB were enrolled in this prospective case control study. Blood flow velocity in the middle cerebral artery as well as regional cerebral oxygenation was determined during step changes of PaCO2 between 30, 40, and 50 mmHg. Measurements were conducted intraoperatively during non-pulsatile as well as postoperatively after admission to the ICU under pulsatile blood flow.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-06-11
• Primary Completion: 2012-10-11
• Study Completion: 2013-12-02
• Study First Submitted: 2018-10-30
• Status Verified: 2018-11
• Study First Submitted QC: 2018-11-04
• Last Update Submitted: 2018-11-04
• Study First Posted: 2018-11-06
• Last Update Posted: 2018-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• undergoing elective cardiac surgery with cardiopulmonary bypass

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Exclusion Criteria

• Carotid artery stenosis (> 50%)
• Neurological pathologies
• COPD with CO2 retention
• Women of childbearing age

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
pulsatile blood flow	alteration of PaCO2 level	-
non-pulsatile blood flow	alteration of PaCO2 level	-

Primary Outcome Measures

Name	Time	Method
CO2- Reactivity of cerebral vessels during cardiopulmonary bypass using nonpulsatile blood flow and postoperative on ICU under physiological pulsatile blood flow	first time-point: intraoperative, during cardiopulmonary bypass, duration up to 300minutes. Second time-point: on ICU, postoperatively under pulsatile blood flow, duration of measurement up to 100minutes for each patient	Relation between PaCO2 level and cerebral blood flow velocity will be assessed during non-pulsatile and pulsatile blood flow. Measurements will be performed using trancranial doppler to measure flow velocity of the middle cerebral artery. Further, NIRS will be used to measure oxygen saturation of the brain. Measurements will be performed during step changes of PaCO2 (at 30mmHg, 40mmHg and 50mmHg.

Trial Locations

Locations (1)

medical University of Vienna; 🇦🇹 Vienna, Austria