Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 256,659
- 主要终点
- Birth outcome - birthweight
研究概览
简要总结
The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pregnant women residing in Swedish localities with a population exceeding 10,000 inhabitants and giving birth during 2012-2018
排除标准
- •Lack of data of PFAS levels in municipal drinking water (entire localities excluded)
- •Mothers not living in the study area consistently between first trimester and four years prior to birth
结局指标
主要结局
Birth outcome - birthweight
时间窗: at birth
grams as measured at birth
Birth outcome - Small for gestational age (SGA)
时间窗: at birth
\<-2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848)
Birth outcome - Large for gestational age (LGA)
时间窗: at birth
\>2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848)
Birth outcome - major congenital malformations
时间窗: at birth
ICD10- codes: Q00-Q99 within the first 28 days postpartum, categorized as major congenital malformations according to European Surveillance of Congenital Anomalies (EUROCAT 2014)
Maternal health - Gestational hypertension/preeclampsia
时间窗: during gestation
ICD10-codes: O13-O14. Diagnosis at maternal or primary care
Maternal health - Gestational diabetes mellus
时间窗: during gestation
ICD10-codes: O24 (excluding pregestational diabetes). Diagnosis at maternal or primary care
次要结局
未报告次要终点
研究者
Agneta Åkesson
Professor
Karolinska Institutet