Effect of low dose injection of ketamine and lumbar epidural pain relief vs thoracic epidural pain relief in patients undergoing major abdominal surgeries: A randomized controlled trial.
Not Applicable
Completed
- Conditions
- Health Condition 1: N939- Abnormal uterine and vaginal bleeding, unspecifiedHealth Condition 2: K318- Other specified diseases of stomach and duodenumHealth Condition 3: null- Patients with 18-70 yrs of age, ASA grade I and II, undergoing elective major abdominal surgery will be enrolled.
- Registration Number
- CTRI/2017/12/010779
- Lead Sponsor
- All India Institute of Medical Sciences Bhubaneswar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
patients with 18-70 yrs of age, ASA grade I and II, undergoing elective major abdominal surgery will be enrolled after taking informed written consent.
Exclusion Criteria
Patients refusing to participate in the study, emergency surgeries, laparoscopic surgeries, re-exploration surgeries, allergy to local anaesthetic drugs, coagulopathies, patients on anticoagulants, more than three attempts for epidural placement and patients who cannot be extubated within 2 hours of surgery will be excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of addition of low dose intravenous ketamine to lumbar epidural analgesia versus thoracic epidural analgesia in reducing postoperative Visual analog scale (VAS) score in patients undergoing major abdominal surgeries.Timepoint: In the post-operative period.
- Secondary Outcome Measures
Name Time Method To establish their effect on inflammatory markers and analgesic consumption.Timepoint: . Three samples for inflammatory markers will be collected at pre-induction, at the end of surgery (at the time of closure) and 24 hours after surgery to measure IL-6, IL-10 and TNF alpha, C reactive protein (CRP) and Serum cortisol.