The role of markers(nlr,il-6,d-dimer) in COVID-19 patients and it’s co-relationship with oxygenation ,a retrospective observational study in Tertiary care covid ICU

Not yet recruiting

• Conditions: Coronavirus as the cause of diseases classified elsewhere, (2) ICD-10 Condition: J09X||Influenza due to identified novelinfluenza A virus, (3) ICD-10 Condition: J111||Influenza due to unidentified influenza virus with other respiratory manifestations,

• Registration Number: CTRI/2020/08/027110
• Lead Sponsor: Vmmc and Safdarjung Hospital

Brief Summary

Although it is a known fact that inflammation is caused by infectious diseases, and growing evidence supports its significant role in the progression of various viral pneumonia, including COVID-19 [7]. Severe inflammatory responses contribute to weak adaptive immune response, thereby resulting in immune response imbalance. Therefore, circulating biomarkers that represent inflammation and immune status are known potential predictors for the prognosis of COVID-19 patients [8]. Peripheral white blood cell (WBC) count, neutrophil (NEU)-to-lymphocyte (LYM) ratio (NLR), derived NLR ratio (d-NLR, neutrophil count divided by the result of WBC count minus neutrophil count), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR),interleukin 6 are indicators of the systemic inflammatory response [9] that are widely investigated as useful predictors for the prognosis of patients with viral pneumonia. By collecting the data from confirmed cases, we will attempt to determine the effect of sex, age, CRP, WBC count, NLR, LMR, PLR, and co morbidities on the prognosis of patients with COVID-19 pneumonia and it’s corelation with lungs oxygenation.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-08-13
• Study Start: 2020-08-22

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

all covid Patient.

Exclusion Criteria

non covid Patient Excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify the level of markers determining outcome of COVID 19 patient	baseline,at 1day,3day,6 day ,7 day

Secondary Outcome Measures

Name	Time	Method
To find the correlation between SpO2/FiO2 and markers for progression of severity of COVID	To find the co-relationship between PaO2/FiO2 and markers for progression of severity of COVID.

Trial Locations

Locations (1)

Vmmc and Safdarjung Hospital; 🇮🇳 South, DELHI, India

Vmmc and Safdarjung Hospital

🇮🇳South, DELHI, India

arin choudhury

Principal investigator

7838756566

arinchoudhury@gmail.com