Do the post operative nausea and vomiting (PONV) drugs Granisetron and Ondansetron negate the analgesic effects of Paracetamol?

Phase 4

• Conditions: Analgesia; Post operative nausea and vomiting; Anaesthesiology - Pain management; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12609000915257
• Lead Sponsor: Dr Paul Sherwin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-10-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

Healthy male volunteers aged 18 to 55 years

Exclusion Criteria

Female, minors, known hypersensitivity to one of the drugs, excessive caffeine consumption (> 4 cups coffee per day), excessive cigarette smoking, illicit drugs, concomitant use of prescription medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain threshold as a indication of the analgesic effect of paracetamol - measured using the PainMatcher[Baseline pain threshold <br>Pain thresholds at 0 mins (T0), 30 mins (T30), 60 mins (T60), 120 mins (T120), 180 mins (T180), 240 mins (T240)]

Secondary Outcome Measures

Name	Time	Method
il[Nil]