Growth Factors in the Treatment of the Multiple Gingival Recessions

Not Applicable

Completed

• Conditions: Gingival Recession; Growth Factors, Combined Defect of
• Interventions: Procedure: CAF only; Procedure: CAF+CGF; Procedure: CAF+A-PRF

• Registration Number: NCT05319938
• Lead Sponsor: Bulent Ecevit University

Brief Summary

The purpose of this study was to compare and evaluate the clinical effects of Concentrated Growth Factor (CGF) and Advanced Platelet-Rich Fibrin (A-PRF) applied together with Coronally Advanced Flap (CAF) technique using a microsurgical approach in the treatment of Type I multiple gingival recessions (GR).

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-01
• Primary Completion: 2020-12-01
• Study Completion: 2020-12-01
• Study First Submitted: 2022-03-11
• Status Verified: 2022-04
• Study First Submitted QC: 2022-04-07
• Last Update Submitted: 2022-04-07
• Study First Posted: 2022-04-11
• Last Update Posted: 2022-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Systematically and periodontally healthy non-smokers
• Presence of Cairo Recession type I gingival recession with ≥ 2 mm gingival recession depth, probing depth <3 mm and gingival thickness (GT) ≥ 0.8 mm on both sides of the maxillary arch
• Width of keratinized gingiva ≥ 2mm
• Presence of identifiable cemento-enamel junction
• Full-mouth plaque index (PI) < 20 %
• Gingival index (GI) scores =1
• Presence of tooth vitality
• Absence of caries, restorations and furcation involvement in the treated area

Exclusion Criteria

• Patients who had systemic problems that wound contraindicate for periodontal surgery
• Usage of medications known to interfere with healing and to cause gingival enlargement
• Recession defects associated with demineralization, deep abrasion, previous surgery in the defects area within the past 1 year
• Pregnant or lactating females
• Drug and alcohol abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CAF only	CAF only	Only Coronally Advanced Flap technique
CAF+CGF	CAF+CGF	Concentrated Growth Factor (CGF) applied together with Coronally Advanced Flap (CAF) technique
CAF+A-PRF	CAF+A-PRF	Advanced Platelet-Rich Fibrin (A-PRF) applied together with Coronally Advanced Flap (CAF) technique

Primary Outcome Measures

Name	Time	Method
Complete and mean root coverage	Change from baseline at 6 months of the percent of complete and mean root coverage	Percentages of root coverage and complete root coverage were calculated according to the following standard formulae.; Percentage of root coverage: \[(preop. vertical gingival recession (VGR)- postop.VGR)\\ preop. VGR\] x 100 Percentage of complete root coverage: \[(teeth with complete root coverage) \\ (all treated teeth)\] x 100.

Secondary Outcome Measures

Name	Time	Method
Hypersensitivity score (HS)	Change from baseline at 6 months of the hypersensitivity score	"Hypersensitivity" score was recorded after blasting air (60 psi, 22°C) derived from a dental syringe that was heading for the root surface for 1 s. The syringe was held at 90° angle, 2-3 mm from the root surface. Neighboring teeth were shielded during testing with the dentist's gloved fingers; then the patient has enquired again to score the discomfort level.; HS: no pain (score 0) → worst pain imaginable (score 10)
Keratinized gingiva width (WKG)	Change from baseline at 6 months of keratinized gingiva width	The WKG was determined by subtracting the VGR from the CEJ- MGJ (mucogingival junction).
Gingival thickness	Change from baseline at 6 months of the gingival thickness	The gingival thickness was evaluated midbuccally in the attached gingival (GT-MB), halfway between the mucogingival junction and free gingival groove and at the base of the interdental papilla. GT was measured by using a periodontal probe with a rubber stopper under local anesthesia, and then the thickness was assessed by transferring to an electronic digital caliper.
Patient esthetic score (PES)	Change from baseline at 6 months of the patient esthetic score	Patient esthetic score (PES) to evaluate esthetic appearance (color, appearance, and form of the selected site),; PES: bad-unlikely esthetics (score 0) → perfect esthetics (score 10)
Patient comfort score (PCS)	Change from baseline at 6 months of the patient comfort score	Patient comfort score (PCS) for the pain, edema and other experiences regarding operating technique, instruments, and microscopic view, etc.; PCS: unbearable discomfort (score 0) → no-discomfort (score 10).

Trial Locations

Locations (1)

Figen Öngöz Dede; 🇹🇷 Ordu, Turkey