Plasticity in Brain Network to Enhance Cognitive Rehabilitation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- Self-report
研究概览
简要总结
Brain injuries affect the lives of numerous Veterans. This study examines how the brain is affected by injury and how rehabilitation training for attention dysfunction may change brain functioning.
详细描述
Traumatic brain injuries (TBI) are a leading cause of long-term disability among combat Veterans. The most common and persistent sequelae after TBI are cognitive-behavioral deficits in 'executive control' and 'attention' functions. Such abnormalities may directly contribute to poor long-term outcomes as well as impede rehabilitation of dysfunction in other cognitive and motor domains. Effective treatments would potentially make a major impact in improving functional outcomes, but consistently effective treatments are not available. The overall goal of this research is to improve the investigators' understanding of plasticity in brain function after TBI and to develop improved cognitive neurorehabilitation treatments. The intervention involves individual and group-based training in cognitive skills.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •history of traumatic brain injury
- •greater than 1 week from injury
- •residual dysfunction related to attention and executive control
排除标准
- •active illicit drug use
- •severe depression
- •contraindications to MRI scanning
研究组 & 干预措施
Goal-oriented Attention Regulation Training
training in goal-directed attention regulation
干预措施: training in goal-directed attention regulation (Behavioral)
Education
brain health education
干预措施: brain health education (Behavioral)
Technology-assisted Goal-directed Self-Regulation Training
computer-assisted training in goal-directed attention regulation
干预措施: computer-assisted training in goal-directed attention regulation (Behavioral)
结局指标
主要结局
Self-report
时间窗: 5 Weeks (After completion of active trainings in Arm 1 and Arm 3)
Responses to goal processing questionnaire relating to areas of personal goal-based functioning. This scale measured participants self-perceived changes to their cognitive and emotional functioning. Participants indicated the degree to which they perceived changes to 11 questions after receiving trainings in Arm 1 and Arm 3 on a 10-point scale (1=domain became worse, 5 = no change, 10 = domain improved). Participants did not complete this measure after Arm 2.
次要结局
- Change From Baseline to Post-training for Task Errors on a Functional Performance Measure(5 weeks (After completion of Arm 1 and Arm 2))
- Change to Attention and Executive Functioning Composite Scores(5 weeks (After completion of Arm 1 and Arm 2))