Improve Acute Reperfusion Treatment Quality for Stroke in China, IMPROVE: Stroke Care in China
Not Applicable
Completed
- Conditions
- Ischemic Stroke
- Interventions
- Behavioral: improvement of quality of stroke care
- Registration Number
- NCT03578107
- Lead Sponsor
- Beijing Tiantan Hospital
- Brief Summary
In order to bridge the great gaps, Chinese Stroke Association (CSA) and American Heart Association (AHA) sought to develop, conduct, and assess a multifaceted quality improvement intervention to increase the adherent rate of IV tPA and ET and improve 3-month clinical outcomes for these patients through our cluster-randomized stepped-wedge IMPROVE: Stroke in China trial.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15895
Inclusion Criteria
Hospitals：
- Voluntary.
- Hospitals from CSCA.
- Secondary or tertiary public hospitals with an emergency department and neurologic wards that receive patients with AIS.
- Have a 24*7 on-call stroke team.
- Have the capacity of IV rt-PA thrombolytic therapy or/and endovascular treatment.
- Implement at least 10 patients' rt-PA or/and endovascular treatment during the last year.
- Admit at least 5 patients of acute ischemic stroke within 24 hours after onset each month.
- Have full desire to improve the procedure of treatment of acute ischemic stroke.
- Have good cooperation among Neurology department, Emergency department, Interventional department, Neurosurgery department, Laboratory and Radiology department.
Patients： Patients who are ≥18 years old were eligible for inclusion if they presented with acute ischemic stroke diagnosed by CT and/or MRI and arrived at hospital within 6 hours after symptom onset.
Exclusion Criteria
Hospitals：
- Hospitals that can not comply with the protocol and finish the research.
- Grade-one hospitals and non cerebral vascular disease specialized hospitals.
- Hospitals involved in other stroke care quality improvement projects or relevant clinical trials.
Patients：
1）Patients refuse to participate in this study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Improvement intervention3 improvement of quality of stroke care receive the following improvement intervention for 6 months： Improvement intervention1 improvement of quality of stroke care receive the following improvement intervention for 18 months： Improvement intervention2 improvement of quality of stroke care receive the following improvement intervention for 12 months：
- Primary Outcome Measures
Name Time Method The adherence rate of guidelines for IV-tPA and/or endovascular treatment in eligible patients. participants will be followed for the duration of hospital stay, an expected average of 2 weeks
- Secondary Outcome Measures
Name Time Method in-hospital mortality participants will be followed for the duration of hospital stay, an expected average of 2 weeks proportional change of intravenous thrombolytic therapy in eligible patients 4.5h after the onset participants will be followed for the duration of hospital stay, an expected average of 2 weeks proportional change of endovascular treatment in eligible patients 6h after the onset participants will be followed for the duration of hospital stay, an expected average of 2 weeks door-to-puncture time participants will be followed for the duration of hospital stay, an expected average of 2 weeks 3-month disability（mRS≥3 ） patients will be followed up at 3 months time from arrival to hospitals to intravenous thrombolytic therapy participants will be followed for the duration of hospital stay, an expected average of 2 weeks
Trial Locations
- Locations (1)
Beijing Tiantan Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China