Epidural hydromorphone vs epidural morphine for the management of pain in patients between 60 to 80 years old with postherpetic neuralgia: a randomized, double-blind, parallel-controlled, non-inferiority study

Science and Technology Commission of Shanghai Municipality0 个研究点目标入组 80 人开始时间: 2019年6月6日最近更新: 2023年8月2日

试验速览

2022 Results article in https://doi.org/10.3389/fphar.2022.1051357 (added 19/07/2023)

•1. 50 years = age = 80 years, regardless of gender.
•2. Active post-herpetic neuralgia with refractory pain more than 30 days after rash onset.
•3. Stable anti-neuropathic-pain therapy according to the guidelines of IASP NeuPSIG (> 7 days), still VAS = 50mm.
•4. Ability to objectively describe symptoms, actively follow the physician's medication recommendation and cooperate with physicians for diagnosis, treatment and follow-up.
•5. Written informed consent to study participation.

•1. Contraindications to epidural catheterization or opioids
•2. Allergy to medications or devices related to the trail
•3. Cognitive deficits compromising the ability to assess pain or pain relief
•4. Previous therapy with hydromorphone or morphine
•5. Pregnancy or breastfeeding
•6. Drug abuse or drug addiction history
•7. Severe hepatic and/or renal impairment
•8. Epidural anesthesia in last 3 months
•9. Participation in other clinical trials that might interfere with the study results

发起方

Science and Technology Commission of Shanghai Municipality