Evaluation of the Psychological Profile of Adult Patients With Prader-Willi Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Perception of life quality through the 36-Item Short Form Survey (SF-36)
研究概览
简要总结
The primary aim of the present study is to investigate the psychological profile of adult patients with PWS and the fatigue experienced by family members. Specifically, the level of psychological well-being, the subjective perception of life quality, and the main characteristics present in terms of psychopathological functioning of subjects with PWS will be investigated. These variables will be investigated in order to detect their presence and the main bonds of interaction, either between them or with other socio-demographic data, in a sample of adults with PWS. At the same time, the presence of psychological distress, levels of well-being quality of life, and coping strategies in family members and caregivers of individuals with PWS will be investigated.
详细描述
The observational study will be carried out at the U.O. of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo.
36 subjects with a genetic diagnosis of PWS, of both sexes and aged between 18 and 55, and their caregivers will be taken into consideration.
In subjects affected by PWS, the following variables will be investigated:
- anthropometric parameters (height, weight, BMI, waist circumference);
- socio-demographic conditions (gender, age, origin, level of education, family composition)
- concomitant hormonal and psychiatric therapies
- intellectual profile through the Mini-Mental State Examination (MMSE), a neuropsychological test consisting of 30 items that refer to the following cognitive areas: orientation in time, orientation in space, word recording, attention and calculation, recall, language, constructional praxis.
- psychological well-being through the Psychological General Well-Being Index (PGWBI), a questionnaire made up of 22 items that measure the following dimensions: anxiety, depression, positivity and well-being, self-control, general state of health, and vitality.
- perception of life quality through the 36-Item Short Form Survey (SF-36), a questionnaire composed of 36 items that investigates the perception of quality of life in relation to: physical functioning, limitations due to physical health, limitations due to emotions, energy and fatigue, emotional well-being, social activities, pain, general health perception
- mental distress through the Symptom Checklist-90-R (SCL-90-R), a questionnaire made up of 90 items capable of investigating the presence and severity of symptoms of mental distress related to nine psychopathological dimensions: somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, anger-hostility, phobic anxiety, paranoid ideation, psychoticism.
The following variables will be investigated in the parents or caregivers of subjects with PWS:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •subjects with a genetic diagnosis of PWS capable of understanding the questionnaires
排除标准
- •subjects with a genetic diagnosis of PWS with cognitive problems (evaluated throughout the Mini-Mental State Examination)
结局指标
主要结局
Perception of life quality through the 36-Item Short Form Survey (SF-36)
时间窗: Baseline
A questionnaire composed of 36 items that investigates the perception of quality of life in relation to: physical functioning, limitations due to physical health, limitations due to emotions, energy and fatigue, emotional well-being, social activities, pain, general health perception
Mental distress through the Symptom Checklist-90-R (SCL-90-R)
时间窗: Baseline
A questionnaire made up of 90 items capable of investigating the presence and severity of symptoms of mental distress related to nine psychopathological dimensions: somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, anger-hostility, phobic anxiety, paranoid ideation, psychoticism.
Psychological well-being through the Psychological General Well-Being Index (PGWBI)
时间窗: Baseline
A neuropsychological test consisting of 30 items that refer to the following cognitive areas: orientation in time, orientation in space, word recording, attention and calculation, recall, language, constructional praxis.
次要结局
- Coping strategies through Coping Orientation to Problem Experienced (COPE-new Italian version).(Baseline (investigated in the parents or caregivers of subjects with PWS))
- Psychological distress through the Depression, Anxiety, and Stress Scale (DASS-21)(Baseline (investigated in the parents or caregivers of subjects with PWS))
- Hyperphagia of subjects with PWS through the Hyperphagia Questionnaire (HQ)(Baseline (investigated in the parents or caregivers of subjects with PWS))