NL-OMON47009已完成不适用
A Cross-over Randomized Controlled Trial; Pulmonary edema detection after fluid loading with blood versus saline in patients after CABG - TACO crossover TRIA
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •1. Age >18 years
- •2. Elective (non-redo) coronary arterial bypass grafting surgery
- •3. Reduced left ventricular ejection fraction (<55%)
- •4. Transfusion of autologous blood (cell saver blood, 300ml, HCT60%, 30min)
- •5. Informed consent
排除标准
- •1. Patients with no indication for autologous RBC transfusion
- •2. Patients with pulmonary hypertension, congenital heart disease, mitral or tricuspid valve disease.
- •3. Contraindications for PAC placement; coagulopathy, bundle branch block, defibrillator or pacemaker (risk of displacement). External pacemaker placed during surgery is no exclusion criterium.
- •4. Patients for acute, non-elective surgery
- •5. Chronic kidney disease stage 4 or higher (eGFR < 30)
- •6. Massive transfusion
- •7. Previous randomization in the current trial
- •8. Postoperative ongoing bleeding
- •9. Bypass duration > 2 hours
- •10. Infusion of high dose corticosteroids
- •11. Hemodynamic instability with a mean arterial pressure (MAP) < 60 mmHg, central venous pressure > 20 mmHg or dependence on high dosages of inotropic drugs after admittance to the ICU
- •12. Severe arrhythmias
- •13. Development of severe pulmonary edema during infusion of autologous blood or saline.
- •14. Elevated liver enzymes
- •15. Iodine allergy
研究者
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