Clinical study for collagen metabolism in patients with coronary heart disease and heart failure with Lixinshui prescriptio
- Conditions
- coronary heart disease and heart failure
- Registration Number
- ITMCTR1900002643
- Lead Sponsor
- Yancheng Hospital of TCM affiliated to Nanjing University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1) Aged 18-80 years, gender is not limited;
2) Meet the diagnostic criteria for coronary heart disease with heartfailure;
3) NYHA heart function level II-IV;
4) Comply with the diagnostic criteria of Chinese medicine heart edema syndrome;
5) Volunteer participation and signing informed consent.
1) Acute exacerbation of chronic heart failure or acute heart failure;
2) Heart failure due to major organ failure such as liver and kidney;
3) The patient may undergo coronary artery bypass grafting or heart transplant surgery within the next 12 weeks; cardiac resynchronization therapy has been or may be performed;
4) Patients with severe primary diseases such as liver and kidney and endocrine and hematopoietic systems;
5) Have mental disorders, or malignant tumors;
6) Pregnant or pregnant women, lactating women;
7) Suspicious or clear allergies to the study drug;
8) Participate in other researchers in the past 2 months;
9) Factors that can aggravate mortality: such as severe ventricular arrhythmia, cardiogenic shock, complete atrioventricular block, obstructive cardiomyopathy, dilated cardiomyopathy, constrictive pericarditis, pericardial tamponade, hemodynamics Unstable unstable heart valve disease, pulmonary embolism, uncontrolled high blood pressure, and severe lung infections.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PICP;
- Secondary Outcome Measures
Name Time Method VMI;NT-proBNP;TCM syndrome points;NYHA;PIIINP;ICTP;MLHFQ;6 minutes walking distance;