跳至主要内容
临床试验/NCT00048958
NCT00048958进行中(未招募)不适用

Cytogenetic Studies in Acute Leukemia and Multiple Myeloma: Companion to CALGB Treatment Studies For Previously Untreated Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Myelodysplastic Syndrome (MDS) or Multiple Myeloma (MM) Patients

Alliance for Clinical Trials in Oncology137 个研究点 分布在 1 个国家目标入组 9,000 人开始时间: 2003年1月27日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
9,000
试验地点
137
主要终点
Correlate specific karyotype groups with selected molecular abnormalities as studied in CALGB leukemia protocols

研究概览

简要总结

Chromosomal analysis or the study of genetic differences in patients previously untreated with AML, ALL, MDS or MM may be helpful in the diagnosis and classification of disease. It may also improve the ability to predict the course of disease and the selection of therapy. Institutions must have either an Alliance-approved cytogeneticist or an agreement from an Alliance-approved main member cytogenetics laboratory to enroll a patient on CALGB 8461. The Alliance Approved Institutional Cytogeneticists list is posted on the Alliance for Clinical Trials in Oncology website.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Correlate specific karyotype groups with selected molecular abnormalities as studied in CALGB leukemia protocols

时间窗: Up to 10 years

To correlate specific karyotype groups with multidrug resistance data

时间窗: Up to 10 years

Determine the incidence of specific less common primary as well as common secondary chromosome abnormalities in adult AML, ALL, MDS and MM

时间窗: Up to 10 years

Correlate specific (normal or various primary and secondary chromosomal abnormalities) with clinical and laboratory parameters

时间窗: Up to 10 years

Correlate specific karyotype groups with response rates, response duration, survival and cure in patients treated with various induction and post-induction regimens

时间窗: Up to 10 years

To correlate specific karyotype groups with epidemiologic data (toxic exposure and family history)

时间窗: Up to 10 years

To determine karyotype changes at relapse and the influence of the type of change (or no change) in karyotype at relapse on subsequent clinical course

时间窗: up to 10 yeras

To identify new chromosome abnormalities important in leukemogenesis

时间窗: Up to 10 years

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (137)

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