Cytogenetic Studies in Acute Leukemia and Multiple Myeloma
- Conditions
- Multiple MyelomaMyelodysplastic SyndromeAcute LeukemiaAcute Lymphoblastic Leukemia
- Interventions
- Genetic: cytogenetic analysis
- Registration Number
- NCT00048958
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Brief Summary
Chromosomal analysis or the study of genetic differences in patients previously untreated with AML, ALL, MDS or MM may be helpful in the diagnosis and classification of disease. It may also improve the ability to predict the course of disease and the selection of therapy. Institutions must have either an Alliance-approved cytogeneticist or an agreement from an Alliance-approved main member cytogenetics laboratory to enroll a patient on CALGB 8461. The Alliance Approved Institutional Cytogeneticists list is posted on the Alliance for Clinical Trials in Oncology website.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 9000
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description No treatment cytogenetic analysis Samples as defined per the protocol for previously untreated patients with AML, ALL, MDS or MM will be submitted for analysis and within one month patients are required to register onto a CALGB treatment study.
- Primary Outcome Measures
Name Time Method To correlate specific karyotype groups with multidrug resistance data Up to 10 years Correlate specific karyotype groups with selected molecular abnormalities as studied in CALGB leukemia protocols Up to 10 years Determine the incidence of specific less common primary as well as common secondary chromosome abnormalities in adult AML, ALL, MDS and MM Up to 10 years Correlate specific (normal or various primary and secondary chromosomal abnormalities) with clinical and laboratory parameters Up to 10 years Correlate specific karyotype groups with response rates, response duration, survival and cure in patients treated with various induction and post-induction regimens Up to 10 years To correlate specific karyotype groups with epidemiologic data (toxic exposure and family history) Up to 10 years To determine karyotype changes at relapse and the influence of the type of change (or no change) in karyotype at relapse on subsequent clinical course up to 10 yeras To identify new chromosome abnormalities important in leukemogenesis Up to 10 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (137)
Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
🇺🇸Baltimore, Maryland, United States
University of Illinois Cancer Center
🇺🇸Chicago, Illinois, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
CCOP - Nevada Cancer Research Foundation
🇺🇸Las Vegas, Nevada, United States
Sunrise Hospital and Medical Center
🇺🇸Las Vegas, Nevada, United States
Veterans Affairs Medical Center - Minneapolis
🇺🇸Minneapolis, Minnesota, United States
Naval Medical Center - San Diego
🇺🇸San Diego, California, United States
UCSF Helen Diller Family Comprehensive Cancer Center
🇺🇸San Francisco, California, United States
Rebecca and John Moores UCSD Cancer Center
🇺🇸La Jolla, California, United States
Tunnell Cancer Center at Beebe Medical Center
🇺🇸Lewes, Delaware, United States
St. Joseph Medical Center
🇺🇸Bloomington, Illinois, United States
Camino Medical Group - Treatment Center
🇺🇸Mountain View, California, United States
Illinois CancerCare - Canton
🇺🇸Canton, Illinois, United States
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
Mason District Hospital
🇺🇸Havana, Illinois, United States
Illinois CancerCare - Macomb
🇺🇸Macomb, Illinois, United States
Holden Comprehensive Cancer Center at University of Iowa
🇺🇸Iowa City, Iowa, United States
Munson Medical Center
🇺🇸Traverse City, Michigan, United States
OSF St. Francis Medical Center
🇺🇸Peoria, Illinois, United States
Illinois Valley Community Hospital
🇺🇸Peru, Illinois, United States
Union Hospital of Cecil County
🇺🇸Elkton, Maryland, United States
Mercy General Health Partners
🇺🇸Muskegon, Michigan, United States
Harold Alfond Center for Cancer Care
🇺🇸Augusta, Maine, United States
Washington Cancer Institute at Washington Hospital Center
🇺🇸Washington, District of Columbia, United States
Evanston Hospital
🇺🇸Evanston, Illinois, United States
Illinois CancerCare - Bloomington
🇺🇸Bloomington, Illinois, United States
Kaiser Permanente Medical Office -Vandever Medical Office
🇺🇸San Diego, California, United States
Graham Hospital
🇺🇸Canton, Illinois, United States
Illinois CancerCare - Eureka
🇺🇸Eureka, Illinois, United States
Galesburg Clinic, PC
🇺🇸Galesburg, Illinois, United States
McDonough District Hospital
🇺🇸Macomb, Illinois, United States
Illinois CancerCare - Carthage
🇺🇸Carthage, Illinois, United States
Memorial Hospital
🇺🇸Carthage, Illinois, United States
CCOP - Christiana Care Health Services
🇺🇸Newark, Delaware, United States
Saint Luke's Hospital - South
🇺🇸Overland Park, Kansas, United States
Butterworth Hospital at Spectrum Health
🇺🇸Grand Rapids, Michigan, United States
CCOP - Mount Sinai Medical Center
🇺🇸Miami Beach, Florida, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
🇺🇸Jupiter, Florida, United States
Illinois CancerCare - Spring Valley
🇺🇸Spring Valley, Illinois, United States
Mecosta County Medical Center
🇺🇸Big Rapids, Michigan, United States
Eureka Community Hospital
🇺🇸Eureka, Illinois, United States
Illinois CancerCare - Galesburg
🇺🇸Galesburg, Illinois, United States
Illinois CancerCare - Kewanee Clinic
🇺🇸Kewanee, Illinois, United States
Illinois CancerCare - Havana
🇺🇸Havana, Illinois, United States
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Illinois CancerCare - Community Cancer Center
🇺🇸Normal, Illinois, United States
CancerCare of Maine at Eastern Maine Medical Center
🇺🇸Bangor, Maine, United States
Community Hospital of Ottawa
🇺🇸Ottawa, Illinois, United States
Illinois CancerCare - Monmouth
🇺🇸Monmouth, Illinois, United States
CCOP - Kansas City
🇺🇸Prairie Village, Kansas, United States
Perry Memorial Hospital
🇺🇸Princeton, Illinois, United States
Masonic Cancer Center at University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Methodist Medical Center of Illinois
🇺🇸Peoria, Illinois, United States
Oncology Hematology Associates of Central Illinois, PC - Ottawa
🇺🇸Ottawa, Illinois, United States
Menorah Medical Center
🇺🇸Overland Park, Kansas, United States
Cancer Treatment Center at Pekin Hospital
🇺🇸Pekin, Illinois, United States
OSF Holy Family Medical Center
🇺🇸Monmouth, Illinois, United States
Goldschmidt Cancer Center
🇺🇸Jefferson City, Missouri, United States
Greenebaum Cancer Center at University of Maryland Medical Center
🇺🇸Baltimore, Maryland, United States
St. Luke's Hospital Cancer Care Center
🇺🇸Duluth, Minnesota, United States
CCOP - Illinois Oncology Research Association
🇺🇸Peoria, Illinois, United States
Illinois CancerCare - Princeton
🇺🇸Princeton, Illinois, United States
Fort Wayne Medical Oncology and Hematology
🇺🇸Fort Wayne, Indiana, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria
🇺🇸Peoria, Illinois, United States
Maine Center for Cancer Medicine and Blood Disorders - Scarborough
🇺🇸Scarborough, Maine, United States
Iowa Blood and Cancer Care
🇺🇸Cedar Rapids, Iowa, United States
Charles R. Wood Cancer Center at Glens Falls Hospital
🇺🇸Glens Falls, New York, United States
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Leo W. Jenkins Cancer Center at ECU Medical School
🇺🇸Greenville, North Carolina, United States
Heartland Regional Medical Center
🇺🇸Saint Joseph, Missouri, United States
Cancer Centers of the Carolinas - Faris Road
🇺🇸Greenville, South Carolina, United States
Cancer Centers of the Carolinas - Grove Commons
🇺🇸Greenville, South Carolina, United States
Greenville Hospital Cancer Center
🇺🇸Greenville, South Carolina, United States
CCOP - Grand Rapids
🇺🇸Grand Rapids, Michigan, United States
Rhode Island Hospital Comprehensive Cancer Center
🇺🇸Providence, Rhode Island, United States
Miriam Hospital
🇺🇸Providence, Rhode Island, United States
Battle Creek Health System Cancer Care Center
🇺🇸Battle Creek, Michigan, United States
McLeod Regional Medical Center
🇺🇸Florence, South Carolina, United States
Danville Regional Medical Center
🇺🇸Danville, Virginia, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
🇺🇸Saint Louis, Missouri, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
🇺🇸Columbia, Missouri, United States
CCOP - North Shore University Hospital
🇺🇸Manhasset, New York, United States
Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
🇺🇸Grand Island, Nebraska, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Lacks Cancer Center at Saint Mary's Health Care
🇺🇸Grand Rapids, Michigan, United States
Spectrum Health Reed City Hospital
🇺🇸Reed City, Michigan, United States
Saint Joseph Oncology, Incorporated
🇺🇸Saint Joseph, Missouri, United States
University Medical Center of Southern Nevada
🇺🇸Las Vegas, Nevada, United States
Southeast Cancer Center
🇺🇸Cape Girardeau, Missouri, United States
Saint Luke's East - Lee's Summit
🇺🇸Lee's Summit, Missouri, United States
Presbyterian Cancer Center at Presbyterian Hospital
🇺🇸Charlotte, North Carolina, United States
CCOP - Greenville
🇺🇸Greenville, South Carolina, United States
CCOP - Hematology-Oncology Associates of Central New York
🇺🇸East Syracuse, New York, United States
Cancer Centers of the Carolinas - Greer Medical Oncology
🇺🇸Greer, South Carolina, United States
Kinston Medical Specialists
🇺🇸Kinston, North Carolina, United States
Missouri Baptist Cancer Center
🇺🇸Saint Louis, Missouri, United States
Cancer Institute of New Jersey at Cooper - Voorhees
🇺🇸Voorhees, New Jersey, United States
Parvin Radiation Oncology
🇺🇸Liberty, Missouri, United States
Monter Cancer Center of the North Shore-LIJ Health System
🇺🇸Lake Success, New York, United States
Callahan Cancer Center at Great Plains Regional Medical Center
🇺🇸North Platte, Nebraska, United States
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
🇺🇸Columbus, Ohio, United States
Mount Sinai Medical Center
🇺🇸New York, New York, United States
Mountainview Medical
🇺🇸Berlin, Vermont, United States
Cancer Centers of the Carolinas - Eastside
🇺🇸Greenville, South Carolina, United States
SUNY Upstate Medical University Hospital
🇺🇸Syracuse, New York, United States
Batte Cancer Center at Northeast Medical Center
🇺🇸Concord, North Carolina, United States
Cancer Centers of the Carolinas - Seneca
🇺🇸Seneca, South Carolina, United States
Don Monti Comprehensive Cancer Center at North Shore University Hospital
🇺🇸Manhasset, New York, United States
Duke Cancer Institute
🇺🇸Durham, North Carolina, United States
New York Weill Cornell Cancer Center at Cornell University
🇺🇸New York, New York, United States
Wayne Memorial Hospital, Incorporated
🇺🇸Goldsboro, North Carolina, United States
Pardee Memorial Hospital
🇺🇸Hendersonville, North Carolina, United States
Long Island Jewish Medical Center
🇺🇸New Hyde Park, New York, United States
Cancer Centers of the Carolinas - Spartanburg
🇺🇸Spartanburg, South Carolina, United States
Mission Hospitals - Memorial Campus
🇺🇸Asheville, North Carolina, United States
Dana-Farber/Brigham and Women's Cancer Center
🇺🇸Boston, Massachusetts, United States
Fletcher Allen Health Care - University Health Center Campus
🇺🇸Burlington, Vermont, United States
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
🇺🇸Fort Lauderdale, Florida, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital
🇺🇸Kansas City, Missouri, United States
North Kansas City Hospital
🇺🇸Kansas City, Missouri, United States
Heartland Hematology Oncology Associates, Incorporated
🇺🇸Kansas City, Missouri, United States
Research Medical Center
🇺🇸Kansas City, Missouri, United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Forsyth Regional Cancer Center at Forsyth Medical Center
🇺🇸Winston-Salem, North Carolina, United States
Wake Forest University Comprehensive Cancer Center
🇺🇸Winston-Salem, North Carolina, United States
Oklahoma University Cancer Institute
🇺🇸Oklahoma City, Oklahoma, United States
Virginia Commonwealth University Massey Cancer Center
🇺🇸Richmond, Virginia, United States
Proctor Hospital
🇺🇸Peoria, Illinois, United States
St. Luke's Hospital
🇺🇸Cedar Rapids, Iowa, United States
BroMenn Regional Medical Center
🇺🇸Normal, Illinois, United States
Community Cancer Center
🇺🇸Normal, Illinois, United States
Illinois CancerCare - Pekin
🇺🇸Pekin, Illinois, United States
Illinois CancerCare - Peru
🇺🇸Peru, Illinois, United States
Mercy Regional Cancer Center at Mercy Medical Center
🇺🇸Cedar Rapids, Iowa, United States