Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder
Recruiting
- Conditions
- OCD
- Interventions
- Other: Functional MRI
- Registration Number
- NCT05843604
- Lead Sponsor
- Centre Hospitalier Henri Laborit
- Brief Summary
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
- Understand and accept the constraints of the study
- Be a beneficiary or affiliated to a Health Insurance scheme
Exclusion Criteria
- Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Have a serious intercurrent pathology
- Being a pregnant woman
- Being a woman of childbearing age without effective contraception.
- Being hospitalized under duress or on an outpatient basis in a care program
- Being under judicial protection (reinforced curatorship, guardianship)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description obsessive compulsive disorder patients Functional MRI - Control Patients Functional MRI -
- Primary Outcome Measures
Name Time Method Cerebral activity modification during N-back task Day 1 Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Cerebral activity modification during Stroop task Day 1 Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Cerebral activity modification during switching task (Monsell et Mizon task ) Day 1 Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre Hospitalier Henri Laborit
🇫🇷Poitiers, France