Impact of Mechanical Insufflation-Exsufflation on Pulmonary and Cognitive Function in Patients with Subacute Stroke
试验速览
- 阶段
- Unknown
- 状态
- 已完成
- 入组人数
- 49
研究概览
简要总结
In a study focusing on subacute stroke patients, it was found that those who underwent Mechanical Insufflation-Exsufflation (MIE) training showed significant improvements in several key areas compared to a control group. These areas include the distance walked in six minutes, cognitive functions (as measured by the Korean version of the Mini-Mental State Examination, Contrasting Program, and Go-no-go tests), and pulmonary function (including Forced Vital Capacity (FVC), the ratio of FVC to predicted normal values, Forced Expiratory Volume in one second (FEV1), the ratio of FEV1 to predicted normal values, Maximum Inspiratory Pressure (MIP), and Maximum Expiratory Pressure (MEP)). Additionally, the study categorized subgroups based on the presence or absence of Exercise-Induced Desaturation (EID) before treatment, finding that improvements in pulmonary function due to MIE training were consistent across these subgroups, indicating that all patients benefited from the intervention regardless of their initial EID status. However, the impact of pulmonary function improvement on walking endurance was found to be differential, potentially more significant in those with pre-treatment EID. This suggests that measuring EID before treatment could contribute to developing effective intervention plans aimed at improving walking endurance. Cognitive functions in stroke patients are often impaired early on, indicating that early intervention in respiratory function could be effective in improving and protecting cognitive functions. In this study, oxygen saturation was not a primary mediator for cognitive functions, suggesting that the mediating effects of pulmonary function improvement on cognitive functions could extend to mechanisms such as immune-mediated neuroplasticity, the interplay between pulmonary function intervention and systemic immune responses, and sleep disorders. This highlights the need for further research into the complex relationships between pulmonary function, cognitive improvement, and systemic health in subacute stroke patients.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 29(Year) 至 78(Year)（—）
- 性别
- All
入选标准
- •a post-stroke duration of more than 3 weeks but less than 6 months, a demonstrable respiratory muscle weakness, as indicated by Maximum Inspiratory Pressure (MIP) and Maximum Expiratory Pressure (MEP) values being less than 70% of the normal range. Additionally, candidates were required to have no thoracic anomalies or deformations, no lung damage or rib fractures, and a score of 18 or above on the Korean Mini-Mental State Examination (K-MMSE), suggesting either normal cognitive function or mild cognitive impairment. Eligibility also depended on the ability to follow instructions, walk independently for at least 6 minutes with or without assistive devices, and a voluntary agreement to participate in the study, understanding its purpose.
排除标准
- •Patients with a history of pulmonary disease, rendering them susceptible to barotrauma, as well as those with a history of stroke or neuromuscular disorders, were excluded from the study.