Microenvironment of Adipose Tissue in Endocannabinoid System
Completed
- Conditions
- Obesity
- Registration Number
- NCT00978289
- Lead Sponsor
- Vanderbilt University
- Brief Summary
The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- BMI>35 kg/m2
- Age 20-60 yrs
- Approved and scheduled for gastric bypass surgery
- Stable body weight for past 3 months
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Exclusion Criteria
- Positive pregnancy test
- Previous gastric surgeries
- Intercurrent infections
- History of ketoacidosis or current metabolic acidosis
- Serum creatinine or liver function tests > 2 times upper limits of normal
- Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States