NCT00978289CompletedNot Applicable
Microenvironment of Adipose Tissue in Endocannabinoid System Before and After Roux-en-y Gastric Bypass Surgery
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Vanderbilt University
- Enrollment
- 20
- Locations
- 1
Study Overview
Brief Summary
The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •BMI>35 kg/m2
- •Age 20-60 yrs
- •Approved and scheduled for gastric bypass surgery
- •Stable body weight for past 3 months
Exclusion Criteria
- •Positive pregnancy test
- •Previous gastric surgeries
- •Intercurrent infections
- •History of ketoacidosis or current metabolic acidosis
- •Serum creatinine or liver function tests > 2 times upper limits of normal
- •Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.
Investigators
Naji Abumrad
Chairman, Department of Surgery
Vanderbilt University
Study Sites (1)
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