Assessment of acute chest pain by computed tomography angiography
Recruiting
- Conditions
- Acute coronary syndrome10011082
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
Patients, >40 years, with acute chest pain, suspected for an acute coronary syndrom
Exclusion Criteria
When immediate coronary angiography is indicated (ST-elevatie myocardial infarction, hemodynamic instability, significant arrhythmia).
When an acute coronary syndrome is very unlikely based on presentation, demographics, risk factors and initial test results.
CT contrast medium allergy, impaired renal function, pregnancy.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1) Accuracy to detect/exclude ACS based on: coronary obstruction, plaque,<br /><br>myocardial enhancement, alternative diagnoses.<br /><br>2) Evaluate the (potential) consequenes of a CT-based approach in terms of:<br /><br>admissions, catheterizations, time, expenses.<br /><br>3) Ability of CT to detect vulnerable plaque (on OCT), based on: plaque<br /><br>density, size, calcification, eccentricity, remodeling.<br /><br></p><br>
- Secondary Outcome Measures
Name Time Method <p>1) Identify patient subcategories in whom CT angiography had most (or least)<br /><br>relevant diagnostic value, based on: demographics, clinical presentation,<br /><br>initial test results: ECG, biomarkers, CT-specific characteristics: heart rate,<br /><br>BMI.<br /><br>2) Correlation between CT angiography and catheter angiography for the<br /><br>detection of coronary stenosis.<br /><br>3) Correlation between CT angiography and exercise testing for the detection of<br /><br>significant coronary artery disease.<br /><br>4) Respective diagnostic contributions of CT angiography, plaque imaging and<br /><br>myocardial enhancement. </p><br>