A Prospective Observational Study on the Effect of Mepolizumab add-on Therapy on Daily Physical Activity in Patients With Severe Eosinophilic Asthma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Severe Eosinophilic Asthma
- Sponsor
- Sotiria General Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Change in daily movement intensity
- Last Updated
- 7 years ago
Overview
Brief Summary
Daily physical activity in adult patients with asthma remains overlooked. Limited evidence demonstrates reduced levels of daily physical activity in asthma populations but studies examining the potential effect of available therapies are missing. This study aims to investigate the overall levels of daily physical activity in patients with severe eosinophilic asthma and whether anti-interleukin-5 therapy with mepolizumab, on top of existing, maximal, and optimised asthma treatment, may improve patient's daily physical activity.
Detailed Description
A multi-centre, prospective, observational study of continuous patients who fulfil the definition of severe asthma and the criteria for mepolizumab (nucala; GSK) therapy. Patients have their daily physical activity recorded using triaxial accelerometry (DynaPort MoveMonitor; McRoberts) prior to treatment, and at 6 and 12 months of mepolizumab therapy (100 mg subcutaneously once every 4 weeks).
Investigators
Marios Panagiotou
Respiratory Physician, PhD student
Sotiria General Hospital
Eligibility Criteria
Inclusion Criteria
- •Severe asthma
- •Criteria for mepolizumab therapy: blood eosinophils ≥150 cells/μL at screening or ≥300 cells/μL in the past 12 months.
Exclusion Criteria
- •Comorbidities limiting physical activity
Outcomes
Primary Outcomes
Change in daily movement intensity
Time Frame: 7 days
Movement intensity in m/s\^2
Change in daily moving time
Time Frame: 7 days
Moving time in minutes
Change in daily time in moderate-to-vigorous-intensity activity
Time Frame: 7 days
Time in moderate-to-vigorous-intensity activity in minutes
Change in daily steps
Time Frame: 7 days
Step count