The Paternal Clock: Uncovering the Consequences of Advanced Paternal Age on Sperm DNA Fragmentation
- Conditions
- Infertility, Male
- Registration Number
- NCT05894356
- Lead Sponsor
- Clinique Ovo
- Brief Summary
Sperm DNA fragmentation (SDF) serves as a marker for chromatin and DNA damage in sperm. Assessing sperm DNA integrity is crucial in male fertility evaluation since high levels of SDF are associated with a greater number of adverse reproductive outcomes, including an increased risk of miscarriage and birth defects.
Recent research suggests that advanced paternal age (APA) may lead to DNA damage in sperm, however the precise age at which this risk becomes apparent has not yet been clearly defined, necessitating the identification of the point in time at which high SDF levels occur. With the help of this knowledge, male infertility can be diagnosed with greater accuracy, and infertile couples can receive appropriate care.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 4250
- Male of at least 18 years of age
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Investigate the impact of advanced paternal age on sperm DNA fragmentation Up to 3 weeks Comparing mean sperm DNA fragmentation throughout the chart review of different age groups
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Clinique Ovo
🇨🇦Montreal, Quebec, Canada
Clinique Ovo🇨🇦Montreal, Quebec, Canada