Establishment of a Tumor Bank for Blood Samples

Recruiting

• Conditions: Neoplasms of the Female Genitalia; Lung Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Ovarian Neoplasms; Endocrine Gland Neoplasms
• Interventions: Other: Blood collection

• Registration Number: NCT01763125
• Lead Sponsor: Medical University of Vienna

Brief Summary

Establishment of a tumor bank, consisting of blood samples of tumor patients and healthy people as controls. The blood samples will be collected systematically together with the corresponding clinical data. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tumor bank.

Detailed Description

Recent progress in diagnosis and therapy of cancer diseases can be ascribed mainly to translational research. The relevance of "translational oncology" will only increase in the future -"From bench to bedside" - the swift implementation of new science research results in clinical studies in order to expedite progress in clinical cancer therapy for the benefit of the patient.

Its almost a matter of course in the medical science today to collect biological samples together with clinical information thereby creating the foundation for future excellent fundamental research.

The aim of this tumor bank is to consist of biological samples (together with a tissue bank - see EK 260/2003) and isolates of tumor patients and healthy people as controls. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tumor bank. The content of the tumor bank can provide essential material for current and future research (e.g. analyses of prognostic or predictive tumor markers; genetically analysis (polymorphism, mutation, hypermethylation; verification and characterisation of disseminated tumor cells).

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2003-11
• Study First Submitted: 2013-01-04
• Study First Submitted QC: 2013-01-07
• Study First Posted: 2013-01-08
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-23
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

• Male/Female
• Age 18 to 90 years max.
• Just one current known malignant disease or
• Just one current inflammatory disease

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Exclusion Criteria

• Inflammatory disease and malignant disease
• multiple malignancies
• multiple diseases
• underage

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Malignant tumors	Blood collection	Patients who have one of the Neoplasms stated above under "conditions". Blood samples will be taken.
Benign controls	Blood collection	Patients with a benign tumor or an inflammatory disease - to be matched by age and affected organ with a patient with a malignant disease. Blood samples will be taken.
Healthy controls	Blood collection	People/patients who have no known disease at time of blood sampling or are admitted to the hospital for minor interventions and have no inflammatory disease. Blood samples will be taken.

Primary Outcome Measures

Name	Time	Method
Establishment of blood/tissue bank consisting of oncological samples from cancer patients and benign and healthy controls.	14 years

Trial Locations

Locations (6)

Innsbruck Medical University; 🇦🇹 Innsbruck, Austria

University Hospitals Leuven - Department of Obstetrics and Gynaecology; 🇧🇪 Leuven, Belgium

University Medical Center Freiburg; 🇩🇪 Freiburg, Germany

Charité University - Campus Virchow Chlinic; 🇩🇪 Berlin, Germany

University Clinic of Ruhr University Bochum; 🇩🇪 Herne, Germany

European Institute of Oncology, Division of Gynecologic Oncology, Unit of Preventive Gynecology; 🇮🇹 Milan, Italy