To explore the immunological basis in women with repeated IVF failure and to study the effect of fat emulsion on natural killer cells during IVF in these wome

Not Applicable

• Conditions: Health Condition 1: O090- Supervision of pregnancy with history of infertility

• Registration Number: CTRI/2019/05/019472
• Lead Sponsor: Indian Council of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

For Subjects

1.History of two or more failed IVF/ICSI cycle.

2.Fresh IVF cycles

3.BMI â?? 19-30 kg/m2

4.Normal menstrual cycles

5.Normal ovarian reserve (AMH > 2ng/ml, FSH <9IU, AFC >8)

6.Factor of infertility â?? unexplained, tubal secondary to ectopic pregnancy and after clipping if hydrosalpinges

7.Normal uterine cavity, as assessed by hysteroscopy or 4D ultrasonography

8.Good quality embryos

9.Normal Partner Semen Analysis including DNA fragmentation index and Reactive oxygen species analysis

For Controls-

1.Volunteer

2.Regular menstrual cycles

3.no history of infertility

4.no hormonal treatment for past three months

Exclusion Criteria

1.Donor oocyte IVF/ICSI

2.Donor Semen IVF

3.Poor Endometrium <7mm

4.Polycystic ovary syndrome

5.OCP use in past three months

6.Previous history of Hysteroscopic adhesiolysis

7.Severe Male factor infertility requiring surgical sperm retrieval

8.Moderate to severe Endometriosis

9.Abnormal parental karyotype

10.History of known immunological and medical disorders like SLE, Rheumatoid Arthritis, diabetes, congenital or acquired blood dyscrasias

11.Clinical or laboratory findings of congenital or acquired thrombophilia

12.Known history of allergic predisposition to soy products, egg products and lecithin

Study & Design

• Study Type: Interventional
• Study Design: Not specified