Defect in human NK cells, HPV infection and development of cancer
Not Applicable
- Conditions
- Health Condition 1: null- Cervical cancer cases,HPV infected women with healthy cervix
- Registration Number
- CTRI/2017/09/009621
- Lead Sponsor
- ICMR National Institute for Research in Reproductive Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Study subjects (from TMH):
Group I.Women with established cervical cancer
Control subjects (from KEM Hospital):
Group II. HPV infected women having normal cervix (PV examination and Pap smear results)
Group III. Women without any genital infection and having normal cervix (PV examination and Pap smear results)
Exclusion Criteria
Women with any other cancer will be excluded from the study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The study will highlight, <br/ ><br>why NK cells fail to recognize the tumor cells that become cancerous. <br/ ><br>Timepoint: <br/ ><br>Study period 3 years
- Secondary Outcome Measures
Name Time Method Comparing the polymorphisms/expression seen in NK cell receptors may highlight, which genes/genotypes or polymorphisms are associated with susceptibility to HPV infection, persistent infection and further with development of cervical cancer. In future, identification of such susceptible or protective host factors/genes may be useful for the benefit of the case management.Timepoint: Study period 3 years