The effect of preoperative intravenous mannitol injection in reducing acute kidney injury following percutaneous nephrolithotomy
Phase 3
Recruiting
- Conditions
- Acute kidney injury, Renal stone, Percutaneous nephrolithotomy (PCNL).Postprocedural (acute) (chronic) kidney failureN99.0
- Registration Number
- IRCT20200110046073N1
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
Patients with renal stone greater than 20 mm in diameter who are candidated for percutaneous nephrolithotomy.
Patients with proximal ureter stone greater than 20 mm in diameter who are candidated for percutaneous nephrolithotomy.
Exclusion Criteria
Heart failure
History of lung embolism
History of deep vein thrombosis
History of brain edema
History of intracranial hemorrhage
Respiratory edema
Anuria
History of digoxin consumption
History of Lithium consumption
History of allergy to mannitol
Electrolite imbalance
Coagolopathies
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post percutaneous nephrolithotomy glomerular filtration rate changes. Timepoint: The day before surgery, 6 hours after surgery, 1, 2, and 14 days after surgery. Method of measurement: cockroft gault equation (based on serum creatinine level).
- Secondary Outcome Measures
Name Time Method Post operative hemoglobin changes. Timepoint: The day before surgery, 6 hours after surgery, 1, 2, and 14 days after surgery. Method of measurement: Complete blood count.;Post operative infection. Timepoint: The day before surgery, 6 hours after surgery, 1, 2, and 14 days after surgery. Method of measurement: Thermometer.