Prehabilitation for Adults With End Stage Renal Disease on the Kidney Transplant Waitlist
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Post kidney transplant mortality
研究概览
简要总结
This pilot study will be a clinical trial to test the feasibility and effectiveness of a kidney transplant (KT) prehabilitation intervention in adults with end stage renal disease (ESRD) who are within 3-6 months of transplantation.
详细描述
Prehabilitation is the enhancement of functional capacity of a patient to improve their ability to withstand a future stressor. The investigators primary objective is to demonstrate feasibility for prehabilitation in Aim 1 and test whether the number of prehabilitation sessions is associated with increased physical activity. The investigators will formally test whether prehabilitation is associated with a reduction in short term and long term KT outcomes as part of Aim 2. The investigators will test whether there is an effect of prehabilitation on short-term (KT length of stay> 2 weeks, early hospital readmission and delayed graft function) and long-term (acute rejection (within the first year), 1 year patient and graft survival) outcomes compared to standard of care controls. Participants will be followed for 3-6 months or until they receive a kidney transplant.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women with end stage renal disease who are within 3-6 months of kidney transplantation and are on the kidney transplant waitlist at Johns Hopkins
- •Must be at least 18 years or older at enrollment
- •Must be English speaking
- •Must be enrolled in an ongoing cohort study of adults with ESRD who are being evaluated for kidney transplantation
- •Must be willing to participate in a prehabilitation program and able to give informed consent
排除标准
- •Patients who have any of the following medical conditions will be excluded from the study:
- •Active Angina pectoris
- •Chronic lung disease and daily use of oxygen
- •Cerebral vascular disease
- •Musculoskeletal conditions that would limit participation in prehabilitation
- •Lower- or upper-extremity amputation
- •Orthopedic disorders exacerbated by physical activity
- •Decreased mental capacity
- •Patients who live outside of Maryland will not be included in the study.
结局指标
主要结局
Post kidney transplant mortality
时间窗: 1 year
1 year patient survival
次要结局
未报告次要终点