Estrogen for the treatment of Borderline Personality Disorder
- Conditions
- Borderline Personality DisorderMental Health - Psychosis and personality disorders
- Registration Number
- ACTRN12617001317381
- Lead Sponsor
- Alfred Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 72
– Age 18-43 years
– Female
– Primary diagnosis of BPD, assessed by the Diagnostic Interview for Borderline Patients (DIB-R)
– Be willing to use appropriate barrier contraceptive precaution for the duration of the study
Known history of breast, endometrial or ovarian cancer
Women aged 40 or over who have not had a normal mammogram in the last 24 months
Abnormal pap smear in the last 24 months
Contraindications to estradiol
Current pregnancy or trying to become pregnant,
History of blood clots (e.g. deep vein thrombosis, pulmonary embolism)
Previous arterial thromboembolic disease (e.g. stroke)
Acute, high risk of suicide such that inpatient admission is required, as determined by PI Kulkarni (psychiatrist) based on her expert clinical assessment.
Taking more than 5 psychotropic medications
Taking OCP that do not have 20, 30 or 35mcg estradiol component
New/ planned changes to psychotropic medication/psychotherapy plans
Consistent, severe substance abuse in last 3 months
Smoking more than 20 cigarettes per day
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method