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Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Completed
Conditions
Ectopic Pregnancy
Registration Number
NCT02793089
Lead Sponsor
IVI Vigo
Brief Summary

This study evaluates the increased risk of ectopic pregnancy associated with marked variation of estradiol during the early luteal phase and high progesterone on hCG day in IVF.

Detailed Description

This is a retrospective cohort study of 578 patients who had no risk of EP (672 fresh transfer IVF cycles) between January 2005 and December 2014. Few studies have reported the relation between hormonal levels and ectopic pregnancy (EP) in IVF. Investigators describe EP incidence according to estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7) or their variation between both days.

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
578
Inclusion Criteria
  • Normal Fallopian tubes in HSG and /or laparoscopy
  • Normal Uterus: Abscence of myomas and Müllerian anomalies .
Exclusion Criteria
  • Previous Ectopic Pregnancy .
  • Recurrent Abortion .
  • Tubal Factor : pelvic inflammatory disease, Hydrosalpinx
  • Previous abdominal surgery (except laparoscopy) .
  • Prior Peritonitis
  • Smoking (at least 1 cigarette/day) .

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Ectopic pregnancy rateUp to 108 months
Secondary Outcome Measures
NameTimeMethod

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