Evaluation of the effect of phytosomal curcumin supplementation in multiple trauma

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 50

Inclusion Criteria

Age 18-70 years
Gastrointestinal tract with normal function and intestinal nutrition criteria
Diagnosis of moderate or severe trauma based on GCS index (4-15)
Trauma diagnosis based on Injury Severity Score (ISS) between minor to severe

Exclusion Criteria

Impossibility of intestinal feeding in the first 48 hours of admission
Any history of heart disease
Patients who are expected to die within 12 hours of admission to the intensive care unit.
Patients who do not have an indication for intestinal nutrition on the first day and are confirmed and predicted based on the diagnosis of the intensive care unit and will not be able to receive intestinal nutrition in the future. (Nausea, persistent vomiting, ileus, intestinal obstruction, uncontrolled diarrhea (> 500 ml / day), high-output fistula (> 500 ml / day), intestinal inaccessibility, incomplete resuscitation and hemodynamic instability
Patients with BMI <18.5kg / m2 admitted to the intensive care unit.
Patients who receive nutritional support through complete intravenous feeding
Patients with a history of underlying disease such as diabetes, congenital and immune disorders, renal and hepatic insufficiency, and pancreatitis.
Taking anticoagulants such as heparin, warfarin, aspirin, etc.
The unwillingness of the patient or his legal guardian to participate in the project
Patients who are hospitalized in the intensive care unit for less than 48 hours
Pregnancy and lactation Severe septic shock or sepsis

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inflammation. Timepoint: Before and after the intervention. Method of measurement: Measurement of inflammatory markers by serum.;Mortality 28 days. Timepoint: Before and after the intervention. Method of measurement: Use existing statistics.;Duration of hospitalization. Timepoint: Before and after the intervention. Method of measurement: Use of questionnaire.

Secondary Outcome Measures