Compare the Safety, Efficacy, and Opioid Consumption of Maxigesic and Paracetamol for Pain Control in the Recovery Room Following Maxillofacial Surgery

Not Applicable

Recruiting

Conditions: Symptoms, signs and abnormal clinical and laboratory findings, NEC

Registration Number: KCT0009639

Lead Sponsor: Seoul National University Dental Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 72

Inclusion Criteria

? Patients aged 19 to 60 years old
? Patients who are American Society of Anesthesiologists physical status I or II
? Patients who are scheduled for double jaw surgery
? Patients with body mass index (BMI) between 18.5 and 30 kg/m2

Exclusion Criteria

? Patients with hypersensitivity or allergy to NSAIDs, opioids, acetaminophen
? Patients taking medications that may affect clinical trial results, such as pain relievers, sedatives, and psychiatric medications
? Patients who are pregnant or breastfeeding
? Patients with liver, kidney or brain dysfunction
? Contraindications to NSAIDs or paracetamol, such as previous gastric ulcer, heart failure, renal failure, thrombocytopenia, liver dysfunction, asthma, nasal polyps, hypersensitivity to the drug, and patients taking heavy alcohol.
? Patients for whom VAS evaluation is expected to be impossible
? Patient with pain before surgery
? Patients weighing less than 50 kg
? Other patients determined by the investigator to be excluded

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Opioid consumption for pain control after orthognathic surgery under general anesthesia between the experimental group and the comparison group

Secondary Outcome Measures

Name	Time	Method
visual analog scale(pain), observer assessment of alertness/sedation scale, blood pressure, pulse rate, oxygen saturation, additional analgesic dose and number of doses, nausea/vomiting occurrence(0=none, 1=nausea, 2=retching, 3=vomiting), presence or absence of shivering, total amount of analgesic administered through PCA, total number of bolus attempts and number of administrations, amount of rescue analgesics, adverse drug reactions, patient satisfaction; Demographic information, visual analog scale(pain);visual analog scale(pain), observer assessment of alertness/sedation scale, blood pressure, pulse oxygen saturation; blood pressure, pulse rate, pulse oxygen saturation, local anesthetics dose, opioids dose during surgery