HLA and perforated peptic ulcer

Not Applicable

• Conditions: Peptic ulcer

• Registration Number: JPRN-UMIN000053659
• Lead Sponsor: Study Group for Gastroenterological Disease

Brief Summary

1. Patients with (n = 303) and without (n = 119) PPU recruited from our member hospitals and more likely to have duodenal ulcers, young, consume alcohol, and smoke. There was no significant difference in sex and ulcer recurrence. Perforated peptic ulcer patients and patients who underwent vagotomy decreased risks of cancer development. 2. Patients harboring HLA-Cw1 and -Cw7 and their heterozygotes protected against PPU development, whereas HLA-Cw3 reduced cancer development.

Detailed Description

Not available

Study Timeline

• Study Completion: 2007-01-15
• Results First Posted: 2023-07-28
• Study Start: 2024-02-26
• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 422

Inclusion Criteria

Not provided

Exclusion Criteria

NP

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical risk factors between peptic ulcer patients who perforated and not and HLA.

Secondary Outcome Measures

Name	Time	Method
lcer recurrence, subsequent gastric cancer and multiple primary malignancy.