Vitamin D supplementation in knee osteoarthritis
Phase 1
Completed
- Conditions
- In this single-arm, prospective controlled interventional trial, a total of 165 KOA patients were recruited based on American College of Rheumatology (ACR) criteria.2 KOA patients aged 50 to 80, whose serum vitamin D levels were below 30 ng/mL were the study'
- Registration Number
- TCTR20230901001
- Lead Sponsor
- ational Research Council of Thailand (N42A650217)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 175
Inclusion Criteria
Knee osteoarthritis patients aged 50 to 80, whose serum vitamin D levels were below 30 ng/mL were the study's intended participants.
Exclusion Criteria
Participants who had had recently undergone knee surgery or who had a history of malignant chronic diseases, such as advanced liver or renal disease, arthritis, protracted knee injury, persistent knee infection, inflammation, or who had used vitamin D supplements within the previous month were excluded. Remarkably, patients who were lost to follow-up or who received treatment beyond clinical palliations fulfil the withdrawal criteria.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum LC3A levels Baseline and 6 months ELISA
- Secondary Outcome Measures
Name Time Method Serum 25(OH)D levels Baseline and 6 months Chemiluminescent immunoassay,Clinical parameters Baseline and 6 months Chemiluminescent immunoassay