Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension

• Conditions: Coarctation of the Aorta

• Registration Number: NCT07134621
• Lead Sponsor: University Medical Centre Ljubljana

Brief Summary

The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta. The main questions it aims to answer are:

* patients with exercise induced hypertension have signs of hypertensive heart disease?

* patients with exercise induced hypertension have increased arterial stiffness?

* patients with exercise induced hypertension have signs of hypertensive renal damage? Participants will be invited for an outpatient appointment during which medical history and physical investigation will be performed. They will undergo cardiopulmonary exercise testing during which blood pressure will be measured regularly. Transthoracic echocardiography will also be performed as well as assessment of arterial stiffness by measuring pulse wave velocity. Renal function will be assessed by blood and urine analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-07-16
• Status Verified: 2025-08
• Study First Submitted: 2025-08-14
• Study First Submitted QC: 2025-08-14
• Last Update Submitted: 2025-08-14
• Study First Posted: 2025-08-21
• Last Update Posted: 2025-08-21
• Primary Completion: 2026-02
• Study Completion: 2026-03-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

adult patients aged 18 years and older with repaired coarctation of aorta.

Exclusion Criteria

haemodynamically significant recoarctation, arterial hypertension at rest, antihypertensive therapy, associated haemodynamically significant valvular heart disease or complex congenital heart disease, advanced heart failure, symptomatic arrhythmias, and cognitive or physical limitations to perform exercise stress testing.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patients with EIH have signs of hypertensive heart disease.	At enrolment.
Patients with EIH have increased arterial stiffness.	At enrolment.
Patients with EIH have signs of hypertensive renal damage.	At enrolment.

Trial Locations

Locations (1)

UMC Ljubljana; 🇸🇮 Ljubljana, Slovenia