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临床试验/NCT07134621
NCT07134621Enrolling By Invitation不适用

Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension

University Medical Centre Ljubljana1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2025年7月16日最近更新:

试验速览

阶段
不适用
状态
Enrolling By Invitation
入组人数
50
试验地点
1
主要终点
Number of patients with EIH who also have signs of hypertensive heart disease.

研究概览

简要总结

The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta. The main questions it aims to answer are:

  • patients with exercise induced hypertension have signs of hypertensive heart disease?
  • patients with exercise induced hypertension have increased arterial stiffness?
  • patients with exercise induced hypertension have signs of hypertensive renal damage? Participants will be invited for an outpatient appointment during which medical history and physical investigation will be performed. They will undergo cardiopulmonary exercise testing during which blood pressure will be measured regularly. Transthoracic echocardiography will also be performed as well as assessment of arterial stiffness by measuring pulse wave velocity. Renal function will be assessed by blood and urine analysis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • adult patients aged 18 years and older
  • history of coarctation of aorta repair

排除标准

  • haemodynamically significant recoarctation
  • arterial hypertension at rest
  • antihypertensive therapy
  • associated haemodynamically significant valvular heart disease
  • associated complex congenital heart disease
  • advanced heart failure
  • symptomatic arrhythmias
  • cognitive or physical limitations to perform exercise stress testing

结局指标

主要结局

Number of patients with EIH who also have signs of hypertensive heart disease.

时间窗: At enrolment.

Number of patients with EIH and increased arterial stiffness.

时间窗: At enrolment.

Number of patients with EIH and signs of hypertensive renal damage.

时间窗: At enrolment.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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