Physical Exercise as a Targeted Therapy in Patients With Chronic Rheumatic Muscle Inflammation
Not Applicable
- Conditions
- Myositis
- Interventions
- Other: Physical Exercise
- Registration Number
- NCT01184625
- Lead Sponsor
- Karolinska Institutet
- Brief Summary
The objectives of this study are to test if hypoxia in muscle tissue is an important factor contributing to clinical symptoms in chronic rheumatic muscle inflammation and to evaluate if a 12 week endurance exercise program will improve muscle tissue hypoxia and disability in patients with chronic rheumatic muscle inflammation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Patients with chronic, stable polymyositis or dermatomyositis with diagnosis of definite or probable polymyositis or dermatomyositis (Bohan and Peter 1975)
- Age 18-80 years
- Duration since diagnosis > 6 months
- Exercising < once a week,
- Stable disease activity and medication for at least one month.
Ten healthy controls matched for age, gender and physical exercise level will be included.
Exclusion Criteria
- Severe pulmonary fibrosis
- Heart or lung conditions that contraindicate vigorous exercise
- Severe osteoporosis
- Not being able to perform the exercise program.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercise Physical Exercise -
- Primary Outcome Measures
Name Time Method Hypoxia related metabolites. After 12 weeks of endurance exercise intervention/ non intervention.
- Secondary Outcome Measures
Name Time Method Muscle impairment. After 12 weeks of endurance exercise intervention/ non intervention.
Trial Locations
- Locations (1)
Rheumatology unit, Karolinska University Hospital
🇸🇪Stockholm, Sweden