NCT01184625Unknown不适用
Physical Exercise as a Targeted Therapy in Patients With Chronic Rheumatic Muscle Inflammation
适应症
干预措施
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Hypoxia related metabolites.
研究概览
简要总结
The objectives of this study are to test if hypoxia in muscle tissue is an important factor contributing to clinical symptoms in chronic rheumatic muscle inflammation and to evaluate if a 12 week endurance exercise program will improve muscle tissue hypoxia and disability in patients with chronic rheumatic muscle inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with chronic, stable polymyositis or dermatomyositis with diagnosis of definite or probable polymyositis or dermatomyositis (Bohan and Peter 1975)
- •Age 18-80 years
- •Duration since diagnosis > 6 months
- •Exercising < once a week,
- •Stable disease activity and medication for at least one month.
- •Ten healthy controls matched for age, gender and physical exercise level will be included.
排除标准
- •Severe pulmonary fibrosis
- •Heart or lung conditions that contraindicate vigorous exercise
- •Severe osteoporosis
- •Not being able to perform the exercise program.
研究组 & 干预措施
Exercise
Experimental
干预措施: Physical Exercise (Other)
No intervention
No Intervention
12 weeks of stable physical exercise level.
结局指标
主要结局
Hypoxia related metabolites.
时间窗: After 12 weeks of endurance exercise intervention/ non intervention.
次要结局
- Muscle impairment.(After 12 weeks of endurance exercise intervention/ non intervention.)
研究者
研究点 (1)
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