Comparison of the effect of two doses of aspirin on the prevention of pre-eclampsia in high risk pregnant wome
Phase 3
- Conditions
- Preeclampsia.Pre-eclampsia
- Registration Number
- IRCT20120918010876N6
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 729
Inclusion Criteria
Pregnant women over 18 years of age
Gestational age of 12-20 weeks
High risk factors for pre-eclampsia (such as multiple pregnancy, chronic hypertension, diabetes mellitus type 1 or 2 , chronic kidney disease, autoimmune disease (antiphospholipid syndrome, lupus)
History of pre-eclampsia or bad outcomes in previous pregnancies
The presence of a viable fetus
Exclusion Criteria
Existence of Cardiovascular, liver, thyroid, hemorrhagic or peptic ulcer diseases
History of asthma
Sensitivity to aspirin
Major fetal disorders
Prolonged use of NSAIDs
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of pre-eclampsia. Timepoint: Monthly up to 28 weeks of pregnancy, then every two weeks up to 36 weeks of pregnancy and eventually every week until the delivery time. Method of measurement: Blood pressure measurement and clinical examination.
- Secondary Outcome Measures
Name Time Method