Effects of exercise on the immune system in pediatric acute lymphoblastic leukemia (ALL) patients.
Completed
- Conditions
- Cancer of the blood10024324
- Registration Number
- NL-OMON36567
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
•Diagnosis of Acute lymphoblastic leukemia (ALL) with a port-a-cath - medium risk, based on DCOG ALL 10 protocol.
•Sufficiently healthy to participate
•A minimal body mass of 25 kg will be required, in order to allow repeated blood sampling
Exclusion Criteria
•Down syndrome or children with multiple morbidity
•Non-ambulation: patients who are unable to ambulate or who will not be able to complete any part of the study protocol due to the severe physical limitations will be excluded
•Unable to cooperate with testing procedures (e.g. insufficient understanding of Dutch language)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the change in inflammatory markers before and after<br /><br>different bouts of exercise.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Correlation between exercise-induced change in inflammatory markers and<br /><br>physical fitness (VO2peak)<br /><br><br /><br>• Correlation between changes in inflammatory markers (e.g NK cells, IL-6,<br /><br>IL-8, IL-10, C-reactive protein and TNF-a) and neutrophil function.<br /><br><br /><br>• Difference in enjoyment between the 3 different exercise training sessions</p><br>