Recording High Frequency Oscillations in Patients With Tumors and Epilepsy

• Conditions: Tumor; Epilepsy
• Interventions: Behavioral: cognitive testing

• Registration Number: NCT02320136
• Lead Sponsor: University of Zurich

Brief Summary

The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation.

The investigators want to show that recording of high-frequency oscillations (HFOs) is feasible in our project population both intraoperatively and during presurgical physiological conditions.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2014-12-15
• Study First Submitted QC: 2014-12-18
• Study First Posted: 2014-12-19
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-30
• Last Update Posted: 2023-12-01
• Primary Completion: 2024-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients intend to be treated at the Klinik für Neurochirurgie
• Patients fall into one of the patient groups: (1) Patients with symptomatic epilepsy with focal and/or secondary generalized seizures resistant to medication where a neurosurgical resection is considered as an intervention of epilepsy surgery. (2)Patients where a tumor is planned to be resected that has caused preoperative seizures. (3) Patients where a tumor is planned to be resected that has not caused preoperative seizures.
• Male and Female subjects 18 years to 99 years of age
• Written informed consent after participants' information

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Exclusion Criteria

• contraindications on ethical grounds
• known or suspected non-compliance, drug or alcohol abuse,
• enrolment into a clinical trial within last 4 weeks

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
epilepsy	cognitive testing	epilepsy patients
tumor with epilepsy	cognitive testing	tumor patients with epileptic seizures
tumor without epilepsy	cognitive testing	tumor patients without epileptic seizures

Primary Outcome Measures

Name	Time	Method
HFO (high-frequency oscillations) occurrence	1 week