on-Invasively recorded high frequency oscillations as biomarkers in focal epilepsy

Completed

• Conditions: convulsion; epileptic fit; Epileptic seizure; 10039911

• Registration Number: NL-OMON44429
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

-Patients have refractory focal epilepsy (not responding to treatment with anti-epileptic drugs) and are candidates for epilepsy surgery in the University Medical Center Utrecht with pre or intra operative corticography (measuring brains signals during surgery).
- Adults and children over six
- EEG and MEG compatible

Exclusion Criteria

-Patients who undergo epilepsy surgery outside the UMCU, or without pre or intra operative corticography
-Patients with metal implants (not MEG compatible)
-Patients under six and other patients unable to lie down or sit motionless for at least 15 minutes (not MEG compatible)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- The number of patients with HFOs with each technique (corticography, scalp<br /><br>EEG, MEG)<br /><br>- The number of HFOs per minute with each technique<br /><br>- The brain aeas showing HFOs with each technique</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The number of seizures before and after surgery<br /><br>- The results of cognitive tests before and after surgery</p><br>