To determine if clinically relevant and statistically significant improvements in asthma control questionnaire score can be achieved and sustained by monitoring bronchial hyperresponsiveness (BHR) to inhaled mannitol in individuals with asthma when compared to assessing spirometry alone.

Sydney Local Health District - Royal Prince Alfred Hospital0 个研究点目标入组 50 人开始时间: 2013年9月5日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•Males and females age 18-75 years
•-Pre-bronchodilator FEV1 greater than or equal to 70% of predicted and greater than 1L
•-A positive response to mannitol challenge (PD15 of less than 635mg)
•-Prescribed ICS treatment after initial challenge
•-Non-smokers; ex-smokers with less than 10 pack years and no cigarettes within the last 12 months
•ACQ score greater than 0.75

•-Evidence of significant cardiovascular, haematological, hepatic, renal, neurological or psychiatric disease or any other major immunological or pulmonary disease other than asthma.
•-Upper or lower respiratory tract infection within 2 weeks of the baseline visit, which may or may not have required a course of oral antibiotics
•-Administration of an investigational drug in the preceding 4 months
•-Subjects positive to mannitol that are being assessed as defence or police recruits

发起方

Sydney Local Health District - Royal Prince Alfred Hospital