Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery

Completed

• Conditions: Acute Lung Injury

• Registration Number: NCT00826072
• Lead Sponsor: Changhai Hospital

Brief Summary

Acute lung injury is a common complication of cardiac surgery with cardiopulmonary bypass, and it is significantly related to prolonged postoperative recovery, hospital stays and medical cost. Currently available predictors of acute lung injury after cardiac surgery are still limited within clinical data. Several genetic polymorphism of inflammatory mediators have been reported to be associated with severity of sepsis and ARDS, but the association of these inflammatory polymorphism and acute lung injury after cardiac surgery has never been reported. This study is performed to investigate the association of genetic polymorphisms including TNF -308A/G, IL-10 -1082A/G and IL-6 -572C/G and postoperative lung injury.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-05
• Primary Completion: 2008-11
• Study Completion: 2009-01
• Study First Submitted: 2009-01-20
• Study First Submitted QC: 2009-01-20
• Study First Posted: 2009-01-21
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-02
• Last Update Posted: 2013-05-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 107

Inclusion Criteria

• Chinese Han unrelated population
• adult patients
• undergoing elective cardiac surgery with CPB

Exclusion Criteria

• malignant tumor
• autoimmune disease, immunodeficiency or immunosuppressive therapy
• chronic renal disease (glomerular filtration rate < 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification>A)
• COPD, tuberculosis or other chronic pulmonary diseases
• anemia with hemoglobin lower than 90mmHg
• bleeding disorders
• postoperative pericardial tamponade requiring re-operation
• postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute lung injury after cardiac surgery with cardiopulmonary bypass	24h after surgery

Secondary Outcome Measures

Name	Time	Method
circulating level of CRP, TNF-alpha, IL-10, IL-6; APACHE Ⅱ score; postoperative kidney injury, duration of ventilation, ICU stay and hospitalization; death in 28 days	24h and 1 month after surgery

Trial Locations

Locations (1)

Changhai Hospital, Second Military Medical University; 🇨🇳 Shanghai, China